Pronunciation: ex-EN-a-tide
Generic Name: Exenatide
Brand Name: Byetta
Exenatide is used for:
Treating type 2 diabetes.
Exenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It lowers blood sugar by increasing the release of insulin from the pancreas. It also mimics the actions of certain hormones that lower blood sugar levels.
Do NOT use Exenatide if:
- you are allergic to any ingredient in Exenatide
- you have type 1 diabetes
- you have a buildup of ketones in the blood or urine caused by diabetes (diabetic ketoacidosis)
- you have severe kidney problems or severe stomach or bowel problems
Contact your doctor or health care provider right away if any of these apply to you.
Before using Exenatide:
Some medical conditions may interact with Exenatide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of stomach or bowel problems, gallbladder problems (eg, gallstones), inflammation of the pancreas (pancreatitis), high blood triglyceride levels, alcohol abuse, kidney problems or kidney transplant, or if you receive dialysis
- if you are also using insulin
- if you are taking lovastatin
Some MEDICINES MAY INTERACT with Exenatide. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Insulin, meglitinides (eg, repaglinide), sulfonylureas (eg, glipizide), or thiazolidinediones (eg, pioglitazone) because the risk of low blood sugar may be increased
- Angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril), diuretics (eg, furosemide, hydrochlorothiazide), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or other medicines that may affect kidney function (eg, aminoglycoside antibiotics, such as gentamicin; amphotericin B; cyclosporine; tacrolimus; vancomycin) because the risk of kidney problems may be increased. Ask your doctor if you are unsure if any of your medicines might affect kidney function
- Anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Exenatide
Ask your health care provider if Exenatide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Exenatide:
Use Exenatide as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Exenatide comes with an extra patient information sheet called a Medication Guide and a user manual for the pen. Read them carefully. Read them again each time you get Exenatide refilled.
- Use Exenatide within 1 hour before your morning and evening meals (or before the 2 main meals of the day), unless your doctor tells you otherwise. Do NOT use it after a meal. Your doses of Exenatide should be about 6 hours or more apart.
- If you will be using Exenatide at home, a health care provider will teach you how to use it. Be sure you understand how to use Exenatide. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not mix Exenatide with insulin. Do not transfer Exenatide from the pen into a syringe or vial.
- Inject Exenatide into your upper leg (thigh), stomach area (abdomen), or upper arm as directed by your doctor or other health care provider.
- Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into a vein or muscle.
- Do not use Exenatide if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- If you are taking certain medicines by mouth (eg, antibiotics, birth control pills), you may need to take them at least 1 hour before you use Exenatide. Ask your doctor, pharmacist, or other health care provider if you need to take any of your medicines at a different time than Exenatide.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Exenatide, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Exenatide.
Important safety information:
- Exenatide may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Exenatide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do NOT use more than the recommended dose without checking with your doctor.
- Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Exenatide exactly as prescribed, tell your doctor.
- Follow the diet and exercise program given to you by your health care provider. Proper diet, regular exercise, and regular testing of blood sugar are important for best results when using Exenatide.
- The risk of low blood sugar may be increased when Exenatide is used with certain other diabetes medicines (eg, insulin, meglitinides, sulfonylureas, thiazolidinediones). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you hungrier. It is a good idea to carry a reliable source of glucose (eg, tablets, gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
- Exenatide may decrease your appetite, the amount of food you eat, and your weight. This is normal. Do not change your dose of Exenatide without checking with your doctor.
- Patients taking Exenatide have developed a severe and sometimes fatal pancreas problem (pancreatitis). Contact your doctor right away if you develop severe or persistent stomach pain that may radiate to the back (with or without nausea or vomiting).
- If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
- Do not store the pen with the needle attached. If the needle is left on, the medicine may leak from the pen or air bubbles may form in the cartridge.
- Lab tests, including hemoglobin A1c levels, blood sugar levels, and kidney function, may be performed while you use Exenatide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Exenatide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Exenatide while you are pregnant. It is not known if Exenatide is found in breast milk. If you are or will be breast-feeding while you use Exenatide, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of Exenatide:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; decreased appetite; diarrhea; dizziness; feeling jittery; headache; indigestion; nausea; vomiting; weakness; weight loss.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); chest pain; fainting; fast heartbeat; severe dizziness; severe or persistent headache, diarrhea, nausea, or vomiting; severe or persistent stomach pain that may radiate to the back (with or without nausea or vomiting); symptoms of kidney problems (eg, change in the amount of urine produced, unusual or persistent pain in the mid to lower back, unexplained swelling); symptoms of low blood sugar (eg, chills, confusion, drowsiness, increased hunger, increased sweating, irritability, nervousness, tremor, blurred vision, weakness).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Exenatide side effects (in more detail)
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness; severe nausea or vomiting; symptoms of low blood sugar (eg, chills, confusion, drowsiness, fainting, fast heartbeat, increased hunger, increased sweating, irritability, nervousness, severe dizziness, tremor, blurred vision, weakness).
Proper storage of Exenatide:
Store unused (unopened) pens in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Do not use Exenatide if it has been frozen. Store used (open) pens below 77 degrees F (25 degrees C). Protect from light. Do not store with the needle attached to the pen. Throw away a used pen 30 days after first use, even if some medicine remains in the pen. Do not use past the expiration date. Keep Exenatide out of the reach of children and away from pets.
General information:
- If you have any questions about Exenatide, please talk with your doctor, pharmacist, or other health care provider.
- Exenatide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Exenatide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
More Exenatide resources
- Exenatide Side Effects (in more detail)
- Exenatide Use in Pregnancy & Breastfeeding
- Exenatide Drug Interactions
- Exenatide Support Group
- 52 Reviews for Exenatide - Add your own review/rating
- Exenatide Professional Patient Advice (Wolters Kluwer)
- Exenatide Monograph (AHFS DI)
- exenatide Subcutaneous Advanced Consumer (Micromedex) - Includes Dosage Information
- exenatide Concise Consumer Information (Cerner Multum)
Compare Exenatide with other medications
- Diabetes, Type 2
No comments:
Post a Comment