Bevacizumab Solution

Pronunciation: BE-va-SIZ-ue-mab
Generic Name: Bevacizumab
Brand Name: Avastin

Serious stomach or bowel problems (eg, abscess, fistula, perforation) may occur with Bevacizumab Solution. These effects are not common, but may be serious and sometimes fatal. Tell your doctor right away if you develop unusual stomach pain along with constipation, fever, nausea, or vomiting.

The incidence of wound healing problems and surgical complications, including serious and sometimes fatal complications, is greater in patients who use Bevacizumab Solution. Tell your doctor immediately if you notice any wounds that do not heal or if you have a surgical wound that opens up. Tell your doctor if you are scheduled to have surgery or if you have had surgery within the past 28 days. If possible, you should not use Bevacizumab Solution within 28 days before or after surgery and until the surgical wound is healed. Talk with your doctor for more information.

The risk of severe and sometimes fatal bleeding problems is increased with Bevacizumab Solution. Patients who have severe bleeding or a recent history of coughing up blood should not use Bevacizumab Solution. Contact your doctor right away if you experience unusual bruising or bleeding, including severe or persistent nosebleed; coughing up blood; black, tarry stools; blood in the vomit or vomit that looks like coffee grounds; unusual or severe vaginal bleeding; or stroke symptoms (eg, confusion, slurred speech, vision problems, one-sided weakness).

Bevacizumab Solution is used for:

Treating certain types of advanced lung cancer. It is also used to treat certain types of brain, kidney, colon, or rectal cancer. It is used with other cancer medicines. It may also be used for other conditions as determined by your doctor.

Bevacizumab Solution is a monoclonal antibody. It works by decreasing the formation and growth of new blood vessels in the tumor by blocking the action of a protein called vascular endothelial growth factor (VEGF). This helps to slow the growth and spread of cancer.

Do NOT use Bevacizumab Solution if:

• you are allergic to any ingredient in Bevacizumab Solution


• you have a tear or hole (perforation) in your stomach or bowels


• you have a wound (including a surgical wound) that has not healed or has split apart


• you have had surgery within the last 28 days


• you have severe bleeding or have recently coughed up blood


• you are taking sunitinib

Contact your doctor or health care provider right away if any of these apply to you.

Before using Bevacizumab Solution:

Some medical conditions may interact with Bevacizumab Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are able to become pregnant


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances, including mouse or murine proteins


• if you have a history of chest pain (eg, angina), high blood pressure, heart problems (eg, congestive heart failure, heart disease, heart attack), blood vessel problems (eg, stroke), bleeding problems, blood clots, or coughing up blood


• if you have a history of nervous system problems, stomach or bowel problems, kidney problems, or high amounts of protein in your urine


• if you have a low blood sodium level, a wound that has not fully healed, or if you are scheduled to have surgery

Some MEDICINES MAY INTERACT with Bevacizumab Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Sunitinib because a certain type of severe anemia (eg, hemolytic anemia) may occur


• Anticoagulants (eg, warfarin) because the risk of bleeding may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bevacizumab Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Bevacizumab Solution:

Use Bevacizumab Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Bevacizumab Solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Bevacizumab Solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Bevacizumab Solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Do not use Bevacizumab Solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• Do not shake Bevacizumab Solution.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Bevacizumab Solution, contact your doctor immediately to establish a new dosing schedule.

Ask your health care provider any questions you may have about how to use Bevacizumab Solution.

Important safety information:

• Bevacizumab Solution may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Bevacizumab Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.


• Bevacizumab Solution may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.


• Bevacizumab Solution may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.


• Bevacizumab Solution may increase the risk of blood clots in your arteries or veins. This can lead to serious effects such as stroke, heart attack, or a blood clot in the lung (pulmonary embolism). Tell your doctor right away if you develop symptoms of a blood clot (eg, pain, redness, swelling, or tenderness in an arm or leg; shortness of breath; coughing up blood), symptoms of stroke (eg, confusion, slurred speech, vision problems, one-sided weakness), or symptoms of a heart attack (eg, chest pain; numbness of an arm or leg; fainting; sudden, severe headache or vomiting).


• Bevacizumab Solution may cause a serious brain problem called reversible posterior leukoencephalopathy syndrome (RPLS). If RPLS occurs, symptoms may appear from 16 hours to 1 year after starting Bevacizumab Solution. Contact your doctor right away if you experience severe headache, seizures, sluggishness, confusion, vision changes, or loss of vision.


• Bevacizumab Solution may cause infertility in women. If you are able to become pregnant, discuss any questions or concerns that you have about this information with your doctor.


• Talk with your doctor before you receive any vaccine while you are using Bevacizumab Solution.


• Tell your doctor or dentist that you take Bevacizumab Solution before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including blood pressure, complete blood cell counts, and urine protein levels, may be performed while you use Bevacizumab Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Bevacizumab Solution with caution in the ELDERLY; they may be more sensitive to its effects, especially the risk of blood clotting problems (eg, heart attack, stroke).


• Bevacizumab Solution should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Bevacizumab Solution may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bevacizumab Solution while you are pregnant. If you are able to become pregnant, talk with your doctor or pharmacist about the use of effective birth control while taking Bevacizumab Solution and for at least 6 months following the last dose of Bevacizumab Solution. It is not known if Bevacizumab Solution is found in breast milk. Do not breast-feed while taking Bevacizumab Solution. Do not become pregnant or breast-feed immediately after you stop Bevacizumab Solution. Bevacizumab Solution can stay in your body for a long time after you stop using it. Talk with your doctor about when it may be safe to become pregnant or breast-feed.

Possible side effects of Bevacizumab Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; changes in taste; constipation; diarrhea; dizziness; dry mouth; dry skin; headache; increased thirst; indigestion; loss of appetite; minor nosebleeds; mouth or tongue pain, swelling, or sores; muscle pain; nausea; pain, swelling, or redness at the injection site; stuffy or runny nose; tiredness; voice changes; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in the urine; burning, numbness, or tingling; chest pain; coughing up blood; decreased urination; fainting; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizure; severe or persistent headache or dizziness; severe or persistent nosebleed; severe or persistent stomach pain, constipation, nausea, or vomiting; severe or persistent weakness; shortness of breath; swelling of the hands, ankles, or feet; swelling or pain in the jaw; unusual bruising or bleeding; unusual or severe sweating; unusual weight gain or loss; vision loss, blurred vision, or other vision changes; vomit that looks like coffee grounds; wheezing; wounds that do not heal.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Bevacizumab side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe headache.

Proper storage of Bevacizumab Solution:

Bevacizumab Solution is usually handled and stored by a health care provider. If you are using Bevacizumab Solution at home, store Bevacizumab Solution as directed by your pharmacist or health care provider. Keep Bevacizumab Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Bevacizumab Solution, please talk with your doctor, pharmacist, or other health care provider.


• Bevacizumab Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Bevacizumab Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Bevacizumab resources

• Bevacizumab Side Effects (in more detail)
• Bevacizumab Use in Pregnancy & Breastfeeding
• Bevacizumab Drug Interactions
• Bevacizumab Support Group
• 6 Reviews for Bevacizumab - Add your own review/rating

Compare Bevacizumab with other medications

• Breast Cancer
• Breast Cancer, Metastatic
• Colorectal Cancer
• Glioblastoma Multiforme
• Macular Degeneration
• Malignant Glioma
• Neurofibromatosis
• Non-Small Cell Lung Cancer
• Ovarian Cancer
• Pancreatic Cancer
• Renal Cell Carcinoma
• Solid Tumors

Biopatch

In the US, Biopatch (chlorhexidine topical) is a member of the following drug classes: antiseptic and germicides, mouth and throat products and is used to treat Gingivitis, Mucositis and Periodontitis.

US matches:

• Biopatch


• Biopatch w/Chlorhexidine Gluconate

Ingredient matches for Biopatch

Chlorhexidine

Chlorhexidine digluconate (a derivative of Chlorhexidine) is reported as an ingredient of Biopatch in the following countries:

• United States

International Drug Name Search

Apo-Triazide

Apo-Triazide may be available in the countries listed below.

Ingredient matches for Apo-Triazide

Hydrochlorothiazide

Hydrochlorothiazide is reported as an ingredient of Apo-Triazide in the following countries:

• Canada


• Singapore

Triamterene

Triamterene is reported as an ingredient of Apo-Triazide in the following countries:

• Canada


• Singapore

International Drug Name Search

Saquinavir Mesylate

Saquinavir Mesylate may be available in the countries listed below.

Ingredient matches for Saquinavir Mesylate

Saquinavir

Saquinavir Mesylate (BANM, USAN) is known as Saquinavir in the US.

International Drug Name Search

Glossary

BANM	British Approved Name (Modified)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Biaminthic

Biaminthic may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Biaminthic

Levamisole

Levamisole hydrochloride (a derivative of Levamisole) is reported as an ingredient of Biaminthic in the following countries:

• France

International Drug Name Search

Bromfed DM

Generic Name: brompheniramine, dextromethorphan, and pseudoephedrine (brom fen EER a meen, dex troe me THOR fan, soo doe e FED rin)

Brand Names: Allanhist PDX Drops, Anaplex DM, Anaplex DMX, Andehist DM NR Syrup, Brom Tann, Bromaline DM, Bromdex D, Bromfed DM, Bromhist PDX, Bromhist-DM Drops, Bromophed-DX, Bromph DM, Bromplex DM, BroveX PSE DM, Dallergy DM, EndaCof-DM, Histacol BD Drops, Myphetane DX Cough, Neo DM, PBM Allergy, Pediahist DM Drops, ProHist DM, Q-Tapp DM, Resperal-DM Drops, Robitussin Allergy & Cough, Sildec DM

What is Bromfed DM (brompheniramine, dextromethorphan, and pseudoephedrine)?

Brompheniramine is an antihistamine that reduces the effects of the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of brompheniramine, dextromethorphan, and pseudoephedrine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, and sinus congestion caused by allergies, the common cold, or the flu.

This medicine will not treat a cough that is caused by smoking, asthma, or emphysema.

Brompheniramine, dextromethorphan, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Bromfed DM (brompheniramine, dextromethorphan, and pseudoephedrine)?

Dosage - adults and children 12 years and over: 2 teaspoonfuls every 4 hours. Children 6 to under 12 years: 1 teaspoonful every 4 hours. Children 2 to under 6 years of age: half a teaspoonful every 4 hours. Infants 6 months to under 2 years of age: dosage to be established by a physician. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid. Do not use cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

What should I discuss with my healthcare provider before taking Bromfed DM (brompheniramine, dextromethorphan, and pseudoephedrine)?

Do not use cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate. Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

Ask a doctor or pharmacist if it is safe for you to take this medication if you have:

• 
  

  a blockage in your digestive tract (stomach or intestines), a colostomy or ileostomy;

  
  


• 
  

  diabetes;

  
  


• 
  

  liver or kidney disease;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  cough with mucus, or cough caused by emphysema or chronic bronchitis;

  
  


• 
  

  enlarged prostate or urination problems;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  pheochromocytoma (an adrenal gland tumor); or

  
  


• 
  

  if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

  
  

FDA pregnancy category C. It is not known whether this medication will harm an unborn baby. Do not use cough or cold medicine without medical advice if you are pregnant. This medicine may pass into breast milk and may harm a nursing baby. Antihistamines and decongestants may also slow breast milk production. Do not use cough or cold medicine without medical advice if you are breast-feeding a baby.

How should I take Bromfed DM (brompheniramine, dextromethorphan, and pseudoephedrine)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up.

Dosage - adults and children 12 years and over: 2 teaspoonfuls every 4 hours. Children 6 to under 12 years: 1 teaspoonful every 4 hours. Children 2 to under 6 years of age: half a teaspoonful every 4 hours. Infants 6 months to under 2 years of age: dosage to be established by a physician. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken a cough or cold medicine within the past few days. Store at room temperature away from moisture and heat. Do not freeze.

What happens if I miss a dose?

Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking Bromfed DM (brompheniramine, dextromethorphan, and pseudoephedrine)?

This medicine may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Drinking alcohol can increase certain side effects of this medication. Ask a doctor or pharmacist before using any other cold, allergy, cough, or sleep medicine. Antihistamines, cough suppressants, and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, cough suppressant, or decongestant.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Avoid becoming overheated or dehydrated during exercise and in hot weather. This medication can decrease sweating and you may be more prone to heat stroke.

Bromfed DM (brompheniramine, dextromethorphan, and pseudoephedrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have a serious side effect such as:

• 
  

  fast, slow, or uneven heart rate;

  
  


• 
  

  severe headache, mood changes, hallucinations;

  
  


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  severe dizziness or anxiety, feeling like you might pass out;

  
  


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  tremor, seizure (convulsions);

  
  


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  easy bruising or bleeding, unusual weakness;

  
  


• 
  

  fever;

  
  


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  urinating less than usual or not at all;

  
  


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  feeling short of breath; or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  mild headache;

  
  


• 
  

  mild dizziness, drowsiness;

  
  


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  dry mouth, nose, or throat;

  
  


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  nausea, diarrhea, constipation, upset stomach;

  
  


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  feeling nervous, restless, or irritable;

  
  


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  blurred vision; or

  
  


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  sleep problems (insomnia).

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Bromfed DM (brompheniramine, dextromethorphan, and pseudoephedrine)?

Ask a doctor or pharmacist before using this medicine if you regularly use other medicines that make you sleepy (such as narcotic pain medication, sedatives, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by brompheniramine or dextromethorphan.

Ask a doctor or pharmacist if it is safe for you to take this medication if you are also using any of the following drugs:

• 
  

  atropine (Atreza, Sal-Tropine);

  
  


• 
  

  benztropine (Cogentin);

  
  


• 
  

  topiramate (Topamax);

  
  


• 
  

  zonisamide (Zonegran);

  
  


• 
  

  an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil, Pexeva), sertraline (Zoloft), venlafaxine (Effexor), and others;

  
  


• 
  

  anti-nausea medications such as belladonna (Donnatal), dimenhydrinate (Dramamine), droperidol (Inapsine), methscopolamine (Pamine), or scopolamine (Transderm Scop);

  
  


• 
  

  bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), tolterodine (Detrol), or Urogesic Blue;

  
  


• 
  

  bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva);

  
  


• 
  

  irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Hyomax), or propantheline (Pro Banthine); or

  
  


• 
  

  ulcer medicine such as glycopyrrolate (Robinul) or mepenzolate (Cantil).

  
  

This list is not complete and other drugs may interact with brompheniramine, dextromethorphan, and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Bromfed DM resources

• Bromfed DM Side Effects (in more detail)
• Bromfed DM Use in Pregnancy & Breastfeeding
• Bromfed DM Drug Interactions
• Bromfed DM Support Group
• 0 Reviews for Bromfed DM - Add your own review/rating

• Bromfed DM Prescribing Information (FDA)


• Bromfed DM Elixir MedFacts Consumer Leaflet (Wolters Kluwer)


• Anaplex DMX Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Bromdex D Prescribing Information (FDA)


• Myphetane DX Prescribing Information (FDA)


• Neo DM Suspension MedFacts Consumer Leaflet (Wolters Kluwer)


• Resperal-DM Drops MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Bromfed DM with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about brompheniramine, dextromethorphan, and pseudoephedrine.

See also: Bromfed DM side effects (in more detail)

Eubrain

Eubrain may be available in the countries listed below.

Ingredient matches for Eubrain

Piracetam

Piracetam is reported as an ingredient of Eubrain in the following countries:

• Taiwan

International Drug Name Search